Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecendented in its combination of biology with a ...

We will show that there is a strong form of emergence in cell biology. Beginning with C.D. Broad's classic discussion of emergence, we distinguish two conditions sufficient for emergence. Emergence in biology must be compatible with the thought that all explanations of systemic properties are mechanistic explanations and with their sufficiency. Explanations of systemic properties are always in terms of the properties of the parts within the system. Nonetheless, systemic properties can still be emergent. If the properties of the components (...) within the system cannot be predicted, even in principle, from the behavior of the system's parts within simpler wholes then there also will be systemic properties which cannot be predicted, even in principle, on basis of the behavior of these parts. We show in an explicit case study drawn from molecular cell physiology that biochemical networks display this kind of emergence, even though they deploy only mechanistic explanations. This illustrates emergence and its place in nature. (shrink)

Name der Zeitschrift: Klio Jahrgang: 97 Heft: 1 Seiten: 7-31.

Mechanistic models in molecular systems biology are generally mathematical models of the action of networks of biochemical reactions, involving metabolism, signal transduction, and/or gene expression. They can be either simulated numerically or analyzed analytically. Systems biology integrates quantitative molecular data acquisition with mathematical models to design new experiments, discriminate between alternative mechanisms and explain the molecular basis of cellular properties. At the heart of this approach are mechanistic models of molecular networks. We focus on the articulation and development of mechanistic (...) models, identifying five constraints which guide the articulation of models in molecular systems biology. These constraints are not independent of one another, with the result that modeling becomes an iterative process. We illustrate the use of these constraints in the modeling of the mechanism for bistability in the lac operon. (shrink)

The paper examines needs experienced during the late stage of AIDS with reference to a phenomenological explication of unstructured interviews with persons with acute symptoms of the disease. A distinct pattern of health care needs emerged, characterized by a relative emphasis on the psychosocial as distinct from biomedical or economical aspects of the disease and emotion focused coping strategies. Results are compared with those of other studies and implications for palliative care are discussed. Indo-Pacific Journal of Phenomenology , Volume 1, (...) Edition 1 April 2001. (shrink)

Biological evolution provides a creative fount of complex and subtle adaptations, often surprising the scientists who discover them. However, because evolution is an algorithmic process that transcends the substrate in which it occurs, evolution’s creativity is not limited to nature. Indeed, many researchers in the field of digital evolution have observed their evolving algorithms and organisms subverting their intentions, exposing unrecognized bugs in their code, producing unexpected adaptations, or exhibiting outcomes uncannily convergent with ones in nature. Such stories routinely reveal (...) creativity by evolution in these digital worlds, but they rarely fit into the standard scientific narrative. Instead they are often treated as mere obstacles to be overcome, rather than results that warrant study in their own right. The stories themselves are traded among researchers through oral tradition, but that mode of information transmission is inefficient and prone to error and outright loss. Moreover, the fact that these stories tend to be shared only among practitioners means that many natural scientists do not realize how interesting and lifelike digital organisms are and how natural their evolution can be. To our knowledge, no collection of such anecdotes has been published before. This paper is the crowd-sourced product of researchers in the fields of artificial life and evolutionary computation who have provided first-hand accounts of such cases. It thus serves as a written, fact-checked collection of scientifically important and even entertaining stories. In doing so we also present here substantial evidence that the existence and importance of evolutionary surprises extends beyond the natural world, and may indeed be a universal property of all complex evolving systems. (shrink)

C. Fred Alford interviewed working people, prisoners, and college students in order to discover how people experience evil -- in themselves, in others, and in ...

Most whistleblowers talk as if they never had a choice about whether to blow the whistle. This doesn't mean they acted suddenly, or impulsively, only that they believe they could not have done otherwise. Trying to make sense of this near universal answer to the question "Why did you do it?" the essay draws on narrative theory. Narrative theory distinguishes between actant and sender—that is, between actor and his or her values. This distinction helps to explain what it means to (...) face a difficult choice over something about which one feels one never had a choice. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 26.1 (2002) 24-42 [Access article in PDF] Emmanuel Levinas and Iris Murdoch: Ethics as Exit? C. Fred Alford THE LEVINAS EFFECT it has been called, the ability of Emmanuel Levinas's texts to say anything the reader wants to hear, so that Levinas becomes a deconstructionist, theologian, proto-feminist, or even the reconciler of postmodern ethics and rabbinic Judaism. Talmudic scholar and postmodern philosopher, Levinas has become (...) everything to everyone. Abstract and evocative, writing in what can only be described as the language of prophecy, we pretend we understand what he is talking about, writing in much the same style, so as to say whatever we wanted to say in the first place. Even those who disagree with Levinas generally criticize him from within the framework of his project, sharing his assumptions while trying to make Levinas more Levinassian. 1How might one disrupt the Levinas Effect? By disrupt, I mean criticize Levinas sympathetically, from a perspective outside his "system," but not outside his world. Levinas's world is one in which the self is the enemy not only of the other, but of authentic existence. Iris Murdoch shares this view with Levinas. Like Levinas, Murdoch sees the self as the enemy. "Unselfing," as she calls it, is the means; the end is to overcome totality, which means the subjection of the other to my categories and my experience. Levinas means much the same thing by totality. It is his philosophical idée maîtresse, the troubling tendency of Western thought from Plato to Hegel and beyond."What breaks the drive of consciousness to totality is not an appeal to an abstract social or linguistic whole, but an encounter with the concrete other person." Levinas did not say this, nor did Iris Murdoch. Maria Antonaccio says it in a book about Murdoch, in which she compares Murdoch's views to those of Levinas. What they share, says [End Page 24] Antonaccio, is this critique of totality, even if "Murdoch would reject the language of command, lordship and accusation that pervade Levinas's account." 2Certainly Levinas's language of persecution is one of the most striking aspects of his account, and I will not ignore it. But it is not the most important thing that distinguishes him from Murdoch. One might argue that it is the "concrete other person" that distinguishes Levinas from Murdoch, for in many respects the other is an abstraction for Levinas. "The best way of encountering the Other is not even to notice the color of his eyes!" says Levinas. 3 Only at a distance is the other abstract enough to remind us of infinity.This distinction comes closer to capturing the difference between them. Even more important, Levinas shares Sartre's nausea at the thingyness of the world. Levinas calls it the il y a, the "there is." It is this that makes his account closer to Sartre's than one might imagine, and more distant from Murdoch. This does not, of course, make Levinas wrong. The comparison with Murdoch is a way of getting out from under the Levinas Effect.My goal is to better understand Levinas by comparing him with Murdoch. This requires that Murdoch's philosophy be seriously considered, but perhaps not as seriously as that of Levinas. Murdoch is the other, Levinas the subject. Possibly we will end up understanding the other better than the subject. I The outlines of Levinas's philosophy will be familiar to many readers. I will elaborate upon a story told by Levinas to recount it. 4 Imagine that someone rings your doorbell and disturbs your work. As you walk to the door you are distracted, still thinking about your latest project. It takes you a moment to recognize your neighbor at the door, the one who lives upstairs; as soon as you recognize his face you invite him in. You talk for a while. He tells you his problem, you tell him what you might do to help him. You share some pleasant conversation, and soon enough your neighbor leaves. What you originally experienced... (shrink)

The Holocaust marks a decisive moment in modern suffering in which it becomes almost impossible to find meaning or redemption in the experience. In this study, C. Fred Alford offers a new and thoughtful examination of the experience of suffering. Moving from the Book of Job, an account of meaningful suffering in a God-drenched world, to the work of Primo Levi, who attempted to find meaning in the Holocaust through absolute clarity of insight, he concludes that neither strategy works (...) well in today's world. More effective are the day-to-day coping practices of some survivors. Drawing on testimonies of survivors from the Fortunoff Video Archives, Alford also applies the work of Julia Kristeva and the psychoanalyst Donald Winnicot to his examination of a topic that has been and continues to be central to human experience. (shrink)

The term narcissism is normally used to describe an infatuation with the self so extreme that the interests of others are ignored. However, argues C. Fred Alford, psychoanalytic theory also implies that narcissism can be construed in a positive way, as a striving for perfection wholeness, and control over self and world. In this book, Alford applies the psychoanalytic theory of narcissism to the philosophies of Socrates and Frankfurt School members Max Horkheimer, Theodor Adorno, Herbert Marcuse, and Jurgen Habermas, (...) contending that it can illuminate basic philosophical issues such as the nature of the ideal society, the integrity of the self, and the role of reason in human affairs. (shrink)

Introduction -- Saint Thomas : putting nature into natural law -- Maritain and the love for the natural law -- The new natural law and evolutionary natural law -- International human rights, natural law, and Locke -- Conclusion : evil and the limits of the natural law.

For some time now a number of critics have argued that Juergen Habermas has misinterpreted Freud. The gist of this criticism is that Habermas' interpretation of psychoanalysis as `depth hermeneutics' must violate the intent of Freud's work, which is so deeply grounded in drive theory. In other words, Habermas confuses philosophical reflection with psychoanalysis. This paper takes a somewhat different focus. It examines the consequences of Habermas' interpretation of Freud for Habermas' view of the individual. It is shown that Habermas' (...) interpretation eventuates in an abstract and shadowy view of the individual. It is argued that an alternative view of psychoanalysis, object relations theory, can help locate the source of Habermas' pale view of the individual, and help correct it, without succumbing to `neo-Freudian revisionism'. Object relations theory also suggests that in order to overcome the diminution of the individual in real life it is necessary for political theory to examine seriously the role of the family. Finally, object relations theory generates an interesting criticism of so-called postmodern psychoanalysis—for example, the work of Jacques Lacan. This criticism can help us better understand the relationship between Habermas and modernism. (shrink)

Stephen Yates's objections to Feyerabend's political theory (Inquiry 27 [1984], 137?42) are presented in a way that makes them unnecessarily vulnerable to a rhetorical strategy often employed by Feyerabend. Like many other critics, Yates seems to assume that it is the implausibility of Feyerabend's claims that opens them to refutation, whereas it is really this that makes them such slippery targets of criticism. Rather than claim that Feyerabend's ideal would be virtually impossible to realize, I argue that Feyerabend does not (...) demonstrate why ?democratic relativism? is at all desirable. (shrink)